2-(Bromomethyl)-6-methylpyridine → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878972Notes

Reaction equation

HRID 878972 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1.[CH2:10]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH3:9][C:5]1[N:4]=[C:3]([CH2:2][N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=3)[CH:19]=[CH:18]2)[CH:8]=[CH:7][CH:6]=1.[CH2:10]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:18]1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 125437332-(Bromomethyl)-6-methylpyridineHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184217HCID 68184217, compound

Procedure

The titled compound (26 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 2-(bromomethyl)-6-methylpyridine according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-333fa1fd2e884cd593b986e45bfcbc13
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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