1-(Bromomethyl)-2-phenylbenzene → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878973Notes

Reaction equation

HRID 878973 reaction equation
[C:1]1([C:7]2[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=2[CH2:9]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]([N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([CH2:31][C:32]([OH:34])=[O:33])[CH:29]=2)[CH:24]=[CH:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:7]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH2:9][N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([CH2:31][C:32]([OH:34])=[O:33])[CH:29]=2)[CH:24]=[CH:23]1.[CH2:15]([N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([CH2:31][C:32]([OH:34])=[O:33])[CH:29]=2)[CH:24]=[CH:23]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 2633651-(Bromomethyl)-2-phenylbenzeneHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184355HCID 68184355, compound

Procedure

The titled compound (41 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 2-phenylbenzyl bromide according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-0629518e91f9450aab6bc59a9f38eaf3
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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