4-Phenylbenzyl chloride → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878974Notes

Reaction equation

HRID 878974 reaction equation
[C:1]1([C:7]2[CH:14]=[CH:13][C:10]([CH2:11]Cl)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]([N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([CH2:31][C:32]([OH:34])=[O:33])[CH:29]=2)[CH:24]=[CH:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:7]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:14]=[CH:13][C:10]([CH2:11][N:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([CH2:31][C:32]([OH:34])=[O:33])[CH:29]=3)[CH:24]=[CH:23]2)=[CH:9][CH:8]=1.[CH2:15]([N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([CH2:31][C:32]([OH:34])=[O:33])[CH:29]=2)[CH:24]=[CH:23]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 154634-Phenylbenzyl chlorideHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184356HCID 68184356, compound

Procedure

The titled compound (22 mg) as a light brown solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 4-phenylbenzyl chloride according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-8d083b0994054a96a48043d7ee923732
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

Loading…