Cyclohexane, (bromomethyl)- → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878977Notes

Reaction equation

HRID 878977 reaction equation
C1(CBr)CCCCC1.[CH2:9]([N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=2)[CH:18]=[CH:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH:10]1([CH2:9][N:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=3)[CH:18]=[CH:17]2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1.[CH2:9]([N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=2)[CH:18]=[CH:17]1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 137636Cyclohexane, (bromomethyl)-HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68183781HCID 68183781, compound

Procedure

The titled compound (69 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and cyclohexylmethyl bromide according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-003847a127734dbb83d6e0f6aecb030b
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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