Hydrochloric Acid → HCID 68184366, compound

Participants

Reaction Steps

To an aqueous solution (2 mL) of zinc powder (1.2 g) was added mercury chloride (124 mg) at room temperature, and then the reaction mixture was stirred at room temperature for 30 minutes. To the reaction mixture were added the compound [59] obtained in Example 59 (73 mg), toluene (1 mL), water (1 mL) and concentrated hydrochloric acid (1 mL) at room temperature, and then the reaction mixture was heated at reflux for 4 hours. After cooling to room temperature, the reaction mixture was quenched with water, and extracted with chloroform. The obtained organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give the titled compound (35 mg) as a yellow solid.

Provenance & Evidence