2,6-Dichlorobenzyl chloride → HCID 68183972, compound

HRID 878995Notes

Reaction equation

HRID 878995 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:14]=1[CH2:15]Cl.C(N1C2C(=CC=C(C(O)=O)C=2)C=C1)C1C=CC=CC=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][N:8]2[CH2:15][C:14]2[C:13]([Cl:12])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:21])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 748322,6-Dichlorobenzyl chlorideHCID 179478751-benzyl-1H-indole-6-carboxylic acidHCID 178434209HCID 178434209, compound

Product 1

HCID 68183972HCID 68183972, compoundYield 62%

Procedure

The titled compound (10.4 g) as a white solid was prepared from the 6-bromo-3-methyl-1H-indazole (9.57 g) obtained with the method described in the document (JP 2009-528363 W) and 2,6-dichlorobenzyl chloride (9.79 g) according to the method of the process (1) of Example 66.

Workup

  1. customobtained with the method

Sources & evidence

ORD record
ord-53ec812bc0c84ef5bbca6d7085c67158
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

Loading…