Potassium Hydroxide → potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

HRID 878996Notes

Reaction equation

HRID 878996 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[OH-].[K+:25]>C(O)C>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[K+:25]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 60152151HCID 60152151, compound

Product 1

HCID 131732622potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [97](118 mg) in ethanol (5 mL) was added an aqueous solution of 1N-potassium hydroxide (0.34 mL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (128 mg) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3b0f27bfeff34be3a00018d1257bb4fd
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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