Potassium Hydroxide → HCID 131732623, compound

HRID 878998Notes

Reaction equation

HRID 878998 reaction equation
[Cl:1][C:2]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[OH-].[K+:25]>C(O)C>[Cl:1][C:2]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[K+:25]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 68184442HCID 68184442, compound

Product 1

HCID 131732623HCID 131732623, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [99](37 mg) in ethanol (2 mL) was added an aqueous solution of 1N-potassium hydroxide (106 μL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (38 mg) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-614018f9db7a4510a80ee8208a637425
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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