Potassium Hydroxide → potassium 2-[1-(2-chloro-6-methylbenzyl)-3-methyl-1H-indazole-6-yl]acetate

HRID 879000Notes

Reaction equation

HRID 879000 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[OH-].[K+:25]>C(O)C>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[K+:25]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 60152152HCID 60152152, compound

Product 1

HCID 89914291potassium 2-[1-(2-chloro-6-methylbenzyl)-3-methyl-1H-indazole-6-yl]acetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [102](33.1 mg) in ethanol (3.0 mL) was added an aqueous solution of 1N-potassium hydroxide (0.1 mL) at room temperature, and the solution was concentrated under reduced pressure to give the titled compound (35.5 mg) as a white solid.

Workup

  1. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8a5f394ad5ac443cb90a0893404ad3bf
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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