Potassium Hydroxide → potassium 3-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]propionate

HRID 879003Notes

Reaction equation

HRID 879003 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:12]=2)[C:7]([CH3:19])=[N:6]1.[OH-].[K+:26]>C(O)C>[Cl:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][CH2:15][C:16]([O-:18])=[O:17])[CH:12]=2)[C:7]([CH3:19])=[N:6]1.[K+:26]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 575232193-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]propionic acid

Product 1

HCID 89914412potassium 3-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]propionate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [122](24 mg) in ethanol (2.0 mL) was added an aqueous solution of 1N-potassium hydroxide (65 μL) at room temperature, and the solution was concentrated under reduced pressure to give the titled compound (27 mg) as a yellow solid.

Workup

  1. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8f268585667e4e76bbf9d99423e596c5
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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