5-Bromo-3-fluoropyridine-2-carbonitrile → HCID 178437984, compound

HRID 879011Notes

Reaction equation

HRID 879011 reaction equation
[Br:1][C:2]1[CH:3]=[C:4](F)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH2:11]([Mg]Cl)[CH3:12].ClC1C=CC=C(Cl)C=1C[N:19]1C2C(=NC=C(C(O)=O)C=2)C(C)=N1>>[Br:1][C:2]1[CH:3]=[C:4]2[NH:19][N:9]=[C:8]([CH2:11][CH3:12])[C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 441966805-Bromo-3-fluoropyridine-2-carbonitrileHCID 681838111-(2,6-dichlorobenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridine-6-carboxylic acidHCID 178461633HCID 178461633, compound

Product 1

HCID 178437984HCID 178437984, compound

Procedure

The titled compound (225 mg) as a white solid was prepared from 5-bromo-3-fluoropyridin-2-carbonitrile (201 mg) obtained by the method described in the document (Journal of Organic Chemistry, 2009, Vol. 74, p. 4547) and ethylmagnesium chloride according to the methods of the processes (1) and (2) of Example 153.

Workup

  1. customobtained by the method

Sources & evidence

ORD record
ord-a90160fa915f486fa7ce01beb295c1c4
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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