Potassium Hydroxide → HCID 131732627, compound

HRID 879015Notes

Reaction equation

HRID 879015 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([F:19])([F:18])[C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:20])=[N:6]1.[OH-].[K+:27]>C(O)C>[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([F:19])([F:18])[C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:20])=[N:6]1.[K+:27]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 68184408HCID 68184408, compound

Product 1

HCID 131732627HCID 131732627, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [183](89 mg) in ethanol (2 mL) was added an aqueous solution of 1N-potassium hydroxide (233 μL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (98 mg) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2e69ac8771924631ba621cbd441b105e
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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