Toluene → HCID 67993030, compound

Participants

Reaction Steps

1 g of Cyclohex-3-enyl-1(R)-amine hydrochloride (Example 3 Step A2) and 40 ml of toluene was charged to a flask at RT and the mixture obtained was stirred. To the mixture obtained 1.9 ml of (C2H5)3N was added dropwise, the mixture obtained was stirred for 10 min followed by 1.12 g of phthalic anhydride and the mixture obtained was heated to reflux, with H2O removed under Dean-Stark conditions, until reaction completion (determined by HPLC). The mixture obtained was washed with 0.1 M HCl followed by 5% NaHCO3 and H2O, dried over Na2SO4 and concentrated to dryness. 1.20 g of 2-(cyclohex-3-en-1(R)-yl)-isoindole-1,3-dione in the form of a pale white crystalline solid was obtained.

Provenance & Evidence