HRID879117

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID46311204

Methyl 6-bromo-5-fluoropyridine-2-carboxylate

C7H5BrFNO2

结构：CC1(C)OB(c2c(F)cc(C3(O)CCC3)cc2F)OC1(C)C

HCID70655110

1-[3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutanol

C16H21BF2O3

PRODUCTS

生成物

结构：COC(=O)c1ccc(F)c(-c2c(F)cc(C3(O)CCC3)cc2F)n1

HCID70654768

未命名化合物

收率 71%

PROCEDURE

实验过程

Method 1 was followed using methyl 6-bromo-5-fluoropicolinate (1.0 equiv.) and 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol (1.6 equiv.) at 100° C. for 30 min in microwave to give methyl 6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinate in 71% yield. LC/MS=338.0 (MH+), Rt=0.85 min.

WORKUP

后处理

customat 100° C.
customfor 30 min