2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 2-(2,6-Difluoro-4-(oxetan-3-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Participants

Role	Name	HCID	Charge
Reactant	2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	HCID 5017741	—
Reactant	3-(3,5-Difluorophenyl)oxetane	HCID 70655340	—
Reactant	Butyllithium	HCID 178418339	—
Product	2-(2,6-Difluoro-4-(oxetan-3-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	HCID 70655338	—

Reaction Steps

Method 3 was followed using 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.3 equiv.), butyllithium (1.1 equiv.) and 3-(3,5-difluorophenyl)oxetane (1.0 equiv.) to give 2-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. 1H NMR (400 MHz, <cdcl3>) δ ppm 6.90 (d, J=8.22 Hz, 2H), 5.07 (dd, J=6.06, 8.41 Hz, 2H), 4.70 (t, J=6.26 Hz, 2H), 4.13-4.23 (m, 1H), 1.39 (s, 12H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08987457B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-6976c544e55945b3b1daea006f6b769e
Source note	uspto-grants-2015_03