HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl 6-bromo-5-fluoropyridine-2-carboxylate → Methyl 6-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-5-fluoropicolinate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl 6-bromo-5-fluoropyridine-2-carboxylate | HCID 46311204 | — |
| Edukt | 2-(2,6-Difluoro-4-(oxetan-3-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 70655338 | — |
| Produkt | Methyl 6-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-5-fluoropicolinate | HCID 70655142 | 47% |
Reaktionsschritte
Method 1 was followed using methyl 6-bromo-5-fluoropicolinate (1.2 equiv.) and 2-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.0 equiv.) at 80° C. for 15 min in microwave to give methyl 6-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-5-fluoropicolinate in 47% yield. LC/MS=324.0 (MH+), Rt=0.75 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08987457B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-a5dd75987cd6440d9d3d02a5f0fd5557 |
| Quellennotiz | uspto-grants-2015_03 |