Ethyl 2-cyano-2-(hydroxyimino)acetate → Ethyl 2-amino-2-cyanoacetate

Participants

Reaction Steps

To a solution of ethyl 2-cyano-2-(hydroxyimino)acetate (1 eq) in ethanol (1.4 M) was added PtO2 (0.05 eq) and the solution was put under an H2 atmosphere (4 bar) in a steel bomb and was stirred overnight. The reaction was filtered through a pad of celite, rinsing with CH2Cl2 and upon removal of volatiles in vacuo ethyl 2-amino-2-cyanoacetate was obtained in 89% yield. LC/MS (m/z): 129.0 (MH+), Rt: 0.25 min.

Provenance & Evidence