HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorophenylboronic acid → Methyl 3-amino-6-(2,6-difluorophenyl)-5-fluoropicolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorophenylboronic acid | HCID 2734336 | — |
| Reactant | Methyl 3-amino-6-bromo-5-fluoropicolinate | HCID 72698878 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | Methyl 3-amino-6-(2,6-difluorophenyl)-5-fluoropicolinate | HCID 59226608 | 94% |
Reaction Steps
Method 1 was followed using methyl 3-amino-6-bromo-5-fluoropicolinate (1.0 equiv.) and 2,6-difluorophenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give methyl 3-amino-6-(2,6-difluorophenyl)-5-fluoropicolinate in 94% yield. LCMS (m/z): 283.0 (MH+), Rt=0.76 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987457B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-8cf6f76f4150418db871e091716e482f |
| Source note | uspto-grants-2015_03 |