(3R,4S,5S)-tert-butyl 4-((S)-2-(((benzyloxy)carbonyl)amino)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoate → (3R,4S,5S)-tert-butyl 4-((S)-2-amino-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoate

Participants

Reaction Steps

500 mg (1 mmol) tert.-butyl-(3R,4S,5S)-4-[{N-[(benzyloxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate (intermediate 1) were dissolved in 50 ml Methanol and, after adding 100 mg 10% Palladium on activated carbon, was hydrated at RT for 1 h under atmospheric pressure. The catalyst was then filtered off and the solving agents was removed in a vacuum. 370 mg (quant.) of the title compound were obtained an almost colorless oil.

Provenance & Evidence