HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 31808933, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Benzoylhydrazine | HCID 11955 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- | HCID 77857 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 31808933 | HCID 31808933 | — |
Reaction Steps
200 mg (754 μmol) of N-Boc-L-phenylalanine were dissolved in 8 ml of DMF mixed with 131 μl (754 μmol) of N,N-diisopropylethylamine, 346 mg (2261 μmol) of HOBt, 434 mg (2261 μmol) of EDC, and 411 mg (3015 μmol) of benzoyl hydrazine. The reaction composition was stirred at RT overnight, then evaporated, and the residue purified over preparative HPLC. The yield was 313 mg (95% purity, 100% o. th.) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987209B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-b76a583eb60547daa89e2019ebd7a41e |
| Source note | uspto-grants-2015_03 |