Thionyl Chloride → HCID 86698259, compound

Participants

Reaction Steps

51.2 mg (128 μmol) of 4-({[(2S)-2-amino-3-phenylpropyl]oxy}methyl)benzoic acid sodium trifluoracetate were added to 5 ml of methanol and mixed with 2.4 mg (13 μmol) of 4-toluenesulfonate acid monohydrate. The batch was stirred overnight under reflux. Then, 18.7 μl (256 μmol) of thionyl chloride were added and the composition heated again under reflux for 6 hours. Then the reaction composition was evaporated in the rotating steam boiler and the residue vacuum dried. Thus, 42.3 mg (80% purity, 88% o. th.) of the title compound were obtained which were used in the consecutive reaction without further purification.

Provenance & Evidence