反应详情

温度

120 °C

The reaction mixture of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(2-chloropyridin-4-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)ethyl pivalate (16 mg, 0.025 mmol), 1-methylpiperazine (1 mL) was heated at 120° C. overnight. Then the reaction mixture was washed by sat. NaHCO3, extracted by EtOAc, the organic phase was dried over MgSO4, filtered, concentrated. To the residue was added THF, MeOH, 2N NaOH, the mixture was heated at 45° C. After the reaction finished, the reaction was washed by sat NaHCO3, extracted by EtOAc, the organic phase was dried over MgSO4, filtered, concentrated down and purified by silica gel column, eluting by 0-100% EtOAc in hexanes to give the product. LCMS-ESI+: calc'd for C36H39ClN4O2S: 627.2 (M+H+); Found: 627.3 (M+H+).

1. washThen the reaction mixture was washed by sat. NaHCO3
2. extractionextracted by EtOAc
3. dry with materialthe organic phase was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. additionTo the residue was added THF, MeOH, 2N NaOH
7. temperaturethe mixture was heated at 45° C
8. washthe reaction was washed
9. extractionextracted by EtOAc
10. dry with materialthe organic phase was dried over MgSO4
11. filtrationfiltered
12. concentrationconcentrated down
13. custompurified by silica gel column
14. washeluting by 0-100% EtOAc in hexanes
15. customto give the product