(S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(1-methyl-1H-indazol-5-yl)-2-oxopyridin-1(2H)-yl)benzo[d]thiazol-6-yl)acetate → (S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(5-(1-methyl-1H-indazol-5-yl)-2-oxopyridin-1(2H)-yl)benzo[d]thiazol-6-yl)acetate

HRID 879317Notes

Reaction equation

HRID 879317 reaction equation
[C:1]([O:5][C@@H:6]([C:11]1[C:36]([CH3:37])=[CH:35][C:14]2[N:15]=[C:16]([N:18]3[CH:23]=[CH:22][CH:21]=[C:20](C4C=C5C(=CC=4)N(C)N=C5)[C:19]3=[O:34])[S:17][C:13]=2[C:12]=1[C:38]1[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][CH:39]=1)[C:7]([O:9][CH3:10])=[O:8])([CH3:4])([CH3:3])[CH3:2].[CH3:45][N:46]1[C:54]2[C:49](=[CH:50][C:51](C3C=CC(=O)NC=3)=[CH:52][CH:53]=2)[CH:48]=[N:47]1>>[C:1]([O:5][C@@H:6]([C:11]1[C:36]([CH3:37])=[CH:35][C:14]2[N:15]=[C:16]([N:18]3[CH:23]=[C:22]([C:51]4[CH:50]=[C:49]5[C:54](=[CH:53][CH:52]=4)[N:46]([CH3:45])[N:47]=[CH:48]5)[CH:21]=[CH:20][C:19]3=[O:34])[S:17][C:13]=2[C:12]=1[C:38]1[CH:39]=[CH:40][C:41]([Cl:44])=[CH:42][CH:43]=1)[C:7]([O:9][CH3:10])=[O:8])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 86699834(S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(1-methyl-1H-indazol-5-yl)-2-oxopyridin-1(2H)-yl)benzo[d]thiazol-6-yl)acetateHCID 866998355-(1-methyl-1H-indazol-5-yl)pyridin-2(1H)-one

Product 1

HCID 86699836(S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(5-(1-methyl-1H-indazol-5-yl)-2-oxopyridin-1(2H)-yl)benzo[d]thiazol-6-yl)acetate

Procedure

Compound (S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(5-(1-methyl-1H-indazol-5-yl)-2-oxopyridin-1(2H)-yl)benzo[d]thiazol-6-yl)acetate was prepared following the procedure used to prepare (S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(1-methyl-1H-indazol-5-yl)-2-oxopyridin-1(2H)-yl)benzo[d]thiazol-6-yl)acetate of Example 27, except that 5-(1-methyl-1H-indazol-5-yl)pyridin-2(1H)-one was used instead of 3-(1-methyl-1H-indazol-5-yl)pyridin-2(1H)-one. LCMS-ESI+ (m/z): [M+H]+ calcd for C34H32ClN4O4S: 627.18; Found: 627.2.

Sources & evidence

ORD record
ord-0fc454cf2ff74ed0978b1eae6e21cdf2
Source dataset
uspto-grants-2015_03
Patent number
US08987250B2

Reaction notes

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