Sodium Carbonate → HCID 86700149, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-ethyl 2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (30 mg, 0.049 mmol) in dichloroethane (1 mL) was added Cu(OAc)2 (9 mg, 0.049 mmol), 2-2′-dipyridyl (7.7 mg, 0.049 mmol), cyclopropylboronic acid (8.4 mg, 0.1 mmol), Na2CO3 (10.4 mg, 0.1 mmol). The reaction mixture was heated at 70° C. for 3 hours under air. The reaction mixture was washed by water, extracted by EtOAc, the organic phase was dried over MgSO4, filtered, concentrated down, purified by silica gel column, eluting by 0-100% EtOAc in hexanes to give the product. LCMS-ESI+: calc'd for C37H35ClN4O3S: 651.2 (M+H+). found: 651.3.

Provenance & Evidence