Trimethyl borate → HCID 86700158, compound

Participants

Reaction Steps

To a stirred and cooled (−78° C.) solution of 3-bromo-1-(1-methyl-1H-indazol-5-yl)pyridin-2(1H)-one (87 mg, 0.287 mmol) and trimethylborate (137 μL, 1.234 mmol) in anhydrous THF (5.0 mL) was added n-BuLi (2.5 M in hexane, 0.71 mL) for 10 min. Quenched the reaction by water and then purified by reverse phase HPLC, eluting by 0-100% acetonitrile in H2O with 0.1% TFA to give the desired product. LCMS-ESI+ (m/z): [M+H]+ calcd for C13H13BN3O3: 270.1; found: 270.2.

Provenance & Evidence