Sodium Hydroxide → HCID 86700160, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-yl)ethyl pivalate (15.0 mg, 0.022 mmol) in THF (1.0 mL) and methanol (0.6 mL) was added 1N NaOH solution (0.4 mL, excess). The reaction mixture was stirred at 50° C. for 4 h. The reaction mixture was diluted with EtOAc, extracted with H2O, brine, dried over Na2SO4, filtered and concentrated and purified by flash column chromatography (silica gel, 0 to 100% ethyl acetate/hexanes) to give the desired product. LCMS-ESI+ (m/z): [M+H]+ calcd for C33H32ClN4O3S: 599.2; found: 599.3.

Provenance & Evidence