Potassium Phosphate, Tribasic → HCID 86700162, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (S)-ethyl 2-tert-butoxy-2-(2-(2-chloropyridin-4-yl)-5-methyl-7-(trifluoromethylsulfonyloxy)benzo[d]thiazol-6-yl)acetate (26.0 mg, 0.046 mmol), 1,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2(3H)-one (20.0 mg, 0.069 mmol) and K3PO4 (29.2 mg, 0.138 mmol) in dioxane (1.0 mL) and H2O (0.1 mL) was degassed for 5 min, treated with PdCl2(dppf) (5.0 mg, 0.007 mmol). The resulting mixture was heated at 100° C. for 8 min. The reaction mixture was diluted with EtOAc, extracted with H2O, brine, dried over Na2SO4, filtered and concentrated and purified by flash column chromatography (silica gel, 0 to 100% ethyl acetate/hexanes) to give the desired product. LCMS-ESI+ (m/z): [M+H]+ calcd for C31H32F3N4O7S2: 693.2; found: 693.1.

Provenance & Evidence