7-[4-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-methyl-1,2,3,4-tetrahydroisoquinoline → N'-(4-{1-ethyl-4-[2-(2-methyl-1,2,3,4-tetrahydro-7-isoquinolinyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea

HRID 87937Notes

Reaction equation

HRID 87937 reaction equation
[Br:1][c:2]1[c:3]2[c:4]([n:5][cH:6][cH:7]1)[n:8]([S:22](=[O:23])(=[O:24])[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:9](-[c:11]1[cH:12][cH:13][c:14]3[c:19]([cH:20]1)[CH2:18][N:17]([CH3:21])[CH2:16][CH2:15]3)[cH:10]2.[Br:31][c:32]1[c:33](-[c:39]2[cH:40][cH:41][c:42]([NH:45][C:46]([N:47]([CH3:48])[CH3:49])=[O:50])[cH:43][cH:44]2)[n:34][n:35]([CH2:37][CH3:38])[cH:36]1>>[c:2]1(-[c:32]2[c:33](-[c:39]3[cH:40][cH:41][c:42]([NH:45][C:46]([N:47]([CH3:48])[CH3:49])=[O:50])[cH:43][cH:44]3)[n:34][n:35]([CH2:37][CH3:38])[cH:36]2)[c:3]2[c:4]([n:5][cH:6][cH:7]1)[n:8]([S:22](=[O:23])(=[O:24])[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:9](-[c:11]1[cH:12][cH:13][c:14]3[c:19]([cH:20]1)[CH2:18][N:17]([CH3:21])[CH2:16][CH2:15]3)[cH:10]2

Participants

3

Reactant 2

HCID 689970577-[4-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-methyl-1,2,3,4-tetrahydroisoquinolineHCID 68999367N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea

Product 1

HCID 69001000N'-(4-{1-ethyl-4-[2-(2-methyl-1,2,3,4-tetrahydro-7-isoquinolinyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea

Sources & evidence

ORD record
ord-70fd331bebd1401ca7f79a07271f223d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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