反应详情

To a solution of (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-4-yl)benzo[d]thiazol-6-yl)acetate (100 mg, 0.16 mmol) in DMF (5 mL) was added cesium carbonate (68 mg, 0.208 mmol). The reaction solution was stirred at room temperature for 5 minutes, iodomethane (30 mg, 0.208 mmol) was added. The reaction solution was stirred for 30 minutes and quenched with water. The mixture was concentrated in vacuo and the residue partitioned between ethyl acetate and water. The organic phase was washed with brine, dried (MgSO4) and concentrated to give crude which was purified by chromatographic column to afford the desired product. LCMS-ESI+: calc'd for C36H35ClN4O3S: 639.2 (M+H+); Found: 639.3 (M+H+).

1. stirringThe reaction solution was stirred for 30 minutes
2. customquenched with water
3. concentrationThe mixture was concentrated in vacuo
4. customthe residue partitioned between ethyl acetate and water
5. washThe organic phase was washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated
8. customto give crude which
9. customwas purified by chromatographic column