Acetic Acid → HCID 86700241, compound

Participants

Reaction Steps

To a solution of crude (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-(piperazin-1-yl)pyridin-4-yl)benzo[d]thiazol-6-yl)acetate (0.144 mmol) in ethanol (2.0 mL) was added acetone (0.21 mL) and acetic acid (12 μL, 0.21 mmol) at 0° C. Reaction mixture was stirred for 15 minutes, then sodium cyanoborohydride (10 mg, 0.158 mmol) was added and reaction mixture was warmed to room temperature over 2 h. Reaction mixture was diluted with ethyl acetate, washed with saturated sodium bicarbonate/brine, dried (MgSO4), filtered, concentrated and purified by CombiFlash (0 to 10% MeOH/CH2Cl2) to give product. LCMS-ESI+: calc'd for C34H42ClN4O3S: 622.2 (M+H+); Found: 621.3 (M+H+).

Provenance & Evidence