Potassium Carbonate → HCID 178472574, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (prepared according to WO201059658, 48 mg, 0.184 mmol), (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate (75 mg, 0.142 mmol) and 2M potassium carbonate solution (0.28 mL, 0.568 mmol) in dioxane (1.0 mL) was sparged with nitrogen for 10 minutes, Pd(PPh3)4 (16 mg, 0.014 mmol) was added and reaction mixture was heated in microwave at 100° C. for 1 h. Reaction mixture was diluted with ethyl acetate, washed with brine. The aqueous layer was back extracted with ethyl acetate and the combined organic layer was dried (MgSO4), filtered, concentrated and purified by CombiFlash (0 to 40% EtOAc/Hex) to give product. LCMS-ESI+: calc'd for C34H31ClFN4O3S: 629.2 (M+H+); Found: 629.3 (M+H+).

Provenance & Evidence