Potassium Carbonate → HCID 86700262, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (15 mg, 0.048 mmol), (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate (17 mg, 032 mmol) and 2M potassium carbonate solution (48 μL, 0.096 mmol) in dioxane (0.5 mL) was sparged with nitrogen for 10 minutes, Pd(PPh3)4 (3.7 mg, 0.0032 mmol) was added and reaction mixture was heated at 100° C. for 4 h. Reaction mixture was diluted with ethyl acetate, washed with brine. The aqueous layer was back extracted with ethyl acetate and the combined organic layer was dried (MgSO4), filtered, concentrated and purified by CombiFlash (0 to 20% EtOAc/Hex) to give product. LCMS-ESI+: calc'd for C39H37ClN3O4S: 678.2 (M+H+); Found: 678.3 (M+H+).

Provenance & Evidence