5-Azaindole → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-2-oxoindolin-5-yl)benzo[d]thiazol-6-yl)acetic acid

Participants

Reaction Steps

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-2-oxoindolin-5-yl)benzo[d]thiazol-6-yl)acetic acid was prepared in a similar manner as (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-(3-oxo-1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)pyridin-4-yl)benzo[d]thiazol-6-yl)acetic acid except (S)-ethyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate was used instead of (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate, 1H-pyrrolo[3,2-c]pyridine was used instead 1H-pyrrolo[3,4-c]pyridin-3(2H)-one and Pd(P-tBu3)2 was used instead of Pd2(dba)3 LCMS-ESI+: calc'd C27H25ClN3O3S: 506.0 (M+H+); Found: 506.2 (M+H+). 1H NMR (400 MHz, CD3OD) δ: 9.31 (s, 1H), 9.18 (d, 1H), 8.66 (d, 1H), 8.31 (d, 1H), 7.90 (s, 1H), 7.72-7.70 (m, 1H), 7.63-7.61 (m, 3H), 7.32 (d, 1H), 5.26 (s, 1H), 2.63 (s, 3H), 0.98 (s, 9H).

Provenance & Evidence