(S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate → HCID 86700279, compound

Participants

Reaction Conditions

Reaction Steps

In a 5 mL microwave reaction tube, 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine TFA salt (excess), (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate (26 mg, 0.05 mmol), bis(tri-tert-butylphosphine)palladium(0) (4 mg, 15%), cetyltrimethylammonium bromide (3 mg) were charged with 1 mL toluene, then 1 drop of 50% KOH aqueous solution was added. The reaction was heated to 105° C. for 1 hour. LC-MS of the reaction crude show desired product. The reaction crude was extracted using ethyl acetate form brine. The organic layer was separated, dried over Na2SO4, filtered and concentrated to give crude which was purified by chromatographic column to afford the desired product. LCMS-ESI+: calc'd for C34H34ClN4O3S: 613.1 (M+H+); Found: 613.3 (M+H+).

Provenance & Evidence