1-Isopropylpiperazine → HCID 86700282, compound

Participants

Reaction Conditions

Reaction Steps

In a 5 mL microwave reaction tube, (S)-methyl 2-(2-(4-bromothiazol-2-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (50 mg, 0.08 mmol), isopropylpiperazine (34 mg, 3 eq.), Bis(tri-t-butylphosphine)palladium(0) (3 mg, 15%), cetyltrimethylammonium bromide (4 mg, 0.5 eq.) were charged with 1 mL toluene, then 1 drop of 50% KOH aqueous solution (excess) was added. The reaction was heated to 105° C. for 1 hour. Reaction mixture was purified by HPLC (0.1% TFA in ACN and water) to give desired product. LCMS-ESI+: calc'd for C31H38ClN4O3S2: 613.2 (M+H+); Found: 613.4 (M+H+).

Provenance & Evidence