Methyl iodide → HCID 86700284, compound

Participants

Reaction Steps

To a solution of (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-oxoisoindolin-5-yl)benzo[d]thiazol-6-yl)acetate (94 mg, 0.171 mmol) in DMF (2.0 mL) was added NaH (˜10 mg, 60% oil dispersion) at 0° C. After 15 min, iodomethane (0.016 mL, 0.256 mmol) was added and after 30 min the reaction was allowed to warm to room temperature. Satd. aqueous NH4Cl was added and the reaction was diluted with EtOAc, washed sequentially with 5% aqueous LiCl and brine. The organic layer was dried over Na2SO4, concentrated and purified by flash column chromatography on silica gel using EtOAc to provide the title compound. LCMS-ESI+: calc'd for C31H31ClN2O4S: 563.2 (M+H+); found: 563.2 (M+H+).

Provenance & Evidence