(S)-ethyl 2-(2-(3-bromo-1-methyl-1H-indazol-6-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate → (S)-ethyl 2-(2-(3-bromo-1-methyl-1H-indazol-5-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate

HRID 879494Notes

Reaction equation

HRID 879494 reaction equation
[Br:1]C1C2C(=CC(C3SC4C(C5C=CC(Cl)=CC=5)=C([C@H](OC(C)(C)C)C(OCC)=O)C(C)=CC=4N=3)=CC=2)N(C)N=1.N[C:41]1[C:49]2[C:44](=[CH:45][CH:46]=[C:47]([C:50]3[S:51][C:52]4[C:58]([C:59]5[CH:64]=[CH:63][C:62]([Cl:65])=[CH:61][CH:60]=5)=[C:57]([C@H:66]([O:72][C:73]([CH3:76])([CH3:75])[CH3:74])[C:67]([O:69][CH2:70][CH3:71])=[O:68])[C:56]([CH3:77])=[CH:55][C:53]=4[N:54]=3)[CH:48]=2)[N:43]([CH3:78])[N:42]=1>>[Br:1][C:41]1[C:49]2[C:44](=[CH:45][CH:46]=[C:47]([C:50]3[S:51][C:52]4[C:58]([C:59]5[CH:64]=[CH:63][C:62]([Cl:65])=[CH:61][CH:60]=5)=[C:57]([C@H:66]([O:72][C:73]([CH3:76])([CH3:75])[CH3:74])[C:67]([O:69][CH2:70][CH3:71])=[O:68])[C:56]([CH3:77])=[CH:55][C:53]=4[N:54]=3)[CH:48]=2)[N:43]([CH3:78])[N:42]=1

Participants

3

Reactant 2

HCID 86700308(S)-ethyl 2-(2-(3-bromo-1-methyl-1H-indazol-6-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetateHCID 86700310(S)-ethyl 2-(2-(3-amino-1-methyl-1H-indazol-5-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate

Product 1

HCID 86700311(S)-ethyl 2-(2-(3-bromo-1-methyl-1H-indazol-5-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate

Procedure

prepared in a manner similar to (S)-ethyl 2-(2-(3-bromo-1-methyl-1H-indazol-6-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate except using (S)-ethyl 2-(2-(3-amino-1-methyl-1H-indazol-5-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate instead of (S)-ethyl 2-(2-(3-amino-1-methyl-1H-indazol-6-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate. LCMS-ESI+: calc'd for C30H29BrClN3O3S: 626.1, 628.1, 630.1 (M+H+); Found; 626.1, 628.1, 630.1 (M+H+).

Sources & evidence

ORD record
ord-ef50bb5d0f784cbb891c510837e75e6c
Source dataset
uspto-grants-2015_03
Patent number
US08987250B2

Reaction notes

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