Potassium Carbonate → HCID 86700327, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of tert-butyl 2-(1-methyl-1H-indazol-5-yl)piperazine-1-carboxylate (10 mg, 0.03 mmol), (S)-ethyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (15 mg, 0.03 mmol), and potassium carbonate (41 mg, 0.3 mmol) in DMF (0.5 mL) was heated at 140° C. for 4 hours. The mixture was cooled, and was quenched with water. The mixture was extracted with ethyl acetate, and the organic phase was washed with water and brine, and was dried with sodium sulfate. Concentration and purification by reverse phase HPLC gave tert-butyl 4-(6-((S)-1-tert-butoxy-2-ethoxy-2-oxoethyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-2-yl)-2-(1-methyl-1H-indazol-5-yl)piperazine-1-carboxylate. LCMS-ESI+: calc'd for C39H47ClN5O5S2: 732.3 (M+H+); Found: 732.2 (M+H+).

Provenance & Evidence