Hydrochloric Acid → HCID 86700329, compound

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Reaction Steps

To (2S)-2-tert-butoxy-2-(2-(4-(tert-butoxycarbonyl)-3-(1-methyl-1H-indazol-5-yl)piperazin-1-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid (4 mg) was added hydrochloric acid in 2-propanol (3 mL, 0.5 N, 1.5 mmol). The mixture was stirred for 24 hours. Concentration and purification with reverse phase HPLC gave (2S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(1-methyl-1H-indazol-5-yl)piperazin-1-yl)benzo[d]thiazol-6-yl)acetic acid. LCMS-ESI+: calc'd for C32H35ClN5O3S: 604.2 (M+H+); Found: 604.3 (M+H+). 1H-NMR 400 MHz, (CD3OD) δ 8.10 (s, 1H), 7.97 (s, 1H), 7.72 (m, 1H), 7.6-7.4 (m, 5H), 7.38 (s, 1H), 5.15 (s, 1H), 4.7 (m, 1H), 4.45 (m, 1H), 4.26 (m, 1H), 4.11 (s, 3H), 3.8 (m, 1H), 3.65-3.4 (m, 3H), 2.50 (s, 3H), 0.94 (s, 9H);

Provenance & Evidence