HCID 86700328, compound → HCID 86700334, compound

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(2S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(4-isopropyl-3-(1-methyl-1H-indazol-5-yl)piperazin-1-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid (3.7 mg) was prepared in a similar manner as compound (2S)-2-tert-butoxy-2-(2-(4-(tert-butoxycarbonyl)-3-(1-methyl-1H-indazol-5-yl)piperazin-1-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid except using (2S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(4-isopropyl-3-(1-methyl-1H-indazol-5-yl)piperazin-1-yl)-5-methylbenzo[d]thiazol-6-yl)acetate instead of tert-butyl 4-(6-((S)-1-tert-butoxy-2-ethoxy-2-oxoethyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-2-yl)-2-(1-methyl-1H-indazol-5-yl)piperazine-1-carboxylate. LCMS-ESI+: calc'd for C35H41ClN5O3S: 646.3 (M+H+); Found: 646.3 (M+H+). 1H-NMR 400 MHz, (CD3OD) δ 8.11 (m, 1H), 8.04 (m, 1H), 7.76 (m, 1H), 7.60 (m, 2H), 7.50 (m, 3H), 7.36 (s, 1H), 5.15 (s, 1H), 4.37 (m, 2H), 4.11 (s, 3H), 4.1-3.7 (m, 3H), 3.4 (m, 3H), 2.49 (s, 3H), 1.32 (d, J=6.2 Hz, 3H), 1.24 (d, J=6.7 Hz, 3H), 0.94 (s, 9H).

Provenance & Evidence