Methyl iodide → HCID 89861084, compound

Participants

Reaction Steps

To the TFA salt of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(2-oxo-1,2-dihydropyrimidin-5-yl)phenyl)benzo[d]thiazol-6-yl)acetic acid (94.8 mg, 0.141 mmol) in DMA (3.0 mL) was added K2CO3 (194.4 mg, 1.406 mmol) and methyl iodide (199.6 mg, 0.088 mL, 1.406 mmol). The reaction was stirred at room temperature for 45 minutes, filtered through Celite (ethyl acetate eluent), concentrated, and used without further purification. LCMS-ESI+: calc'd for C32H31ClN3O4S (M+H1): 588.2; Found: 588.2 (M+H+).

Provenance & Evidence