Cesium carbonate → HCID 178472575, compound

Participants

Reaction Conditions

Reaction Steps

A flask was charged with (S)-ethyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (100 mg, 0.20 mmol), 2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine (85 mg, 0.40 mmol), Cs2CO3 (325 mg, 1.0 mmol), and then diluted with ACN (4 mL). The suspension was heated to 80° C. for 24 hours and then allowed to cool to room temperature. The resulting mixture was filtered and concentrated in vacuo. The crude residue was purified by reverse phase column chromatography (5-100% ACN/H2O+0.1% TFA)to afford the desired product. LCMS-ESI+: calc'd for C29H34ClN4O3S: 553.2 (M+H+); Found: 553.2 (M+H+).

Provenance & Evidence