反应详情

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(6-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)benzo[d]thiazol-6-yl)acetic acid was prepared in a similar manner as (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid, except using 1-(oxetan-3-yl)piperazine instead of 1-isopropylpiperazine. LCMS-ESI+: calc'd for C32H36ClN4O4S: 607.2 (M+H+); Found: 607.2 (M+H+); 1H NMR (400 MHz, CD3OD): δ 7.70-7.81 (m, 3H), 7.64 (m, 1H), 7.49-7.56 (m, 3H), 7.04 (d, J=8 Hz, 1H), 5.19 (s, 1H), 4.88 (br m, 2H), 4.77 (br m [under solvent], 4H), 4.35 (m, 1H), 3.80 (br m, 2H), 3.24 (m, [under solvent] 4H), 0.93 (s, 9H).