N-bromobutanimide → HCID 86700378, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 mL round bottom flask, 6-(1-methyl-1H-indazol-5-yl)pyridin-3-amine (225 mg, 1.00 mmol) was dissolved in DMF (8 mL) at room temperature and the solution was cooled down to 0° C. for 5 min under argon atmosphere. A solution of NBS (179 mg, 1.00 mmol) in DMF (6 mL) was added dropwise. The resulting reaction mixture was stirred at 0° C. for 30 min and then was poured onto saturated aq NaHCO3 solution (30 mL). EtOAc (3×30 mL) was used for extraction. Organic phase was then washed with water (2×20 mL) and concentrated. Residue was purified on silica gel column with 0-30% to afford product. LCMS-ESI+: calc'd for: C13H11BrN4: 303.0, 305.0 (M+H+); found: 303.1, 305.1 (M+H+)

Provenance & Evidence