HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 879590Generated: November 1, 2026
Diisopropylethylamine → HCID 86700404, compound
https://huagongshe.com/reaction/879590
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(4-chlorophenyl)-2-methylmorpholine | HCID 3066043 | — |
| Reactant | (S)-ethyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate | HCID 86700141 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86700404 | HCID 86700404 | — |
Reaction Steps
A mixture of (S)-ethyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate, 2-(4-chlorophenyl)-2-methylmorpholine and iPr2NEt (20.1 mg, 0.156 mmol) in DMF was heated at 100° C. for 10 hours. The mixture was evaporated to dryness and separated on CombiFlash, eluting with 0-70% EtOAc/Hex to give title compound. LCMS-ESI+: calc'd for C33H36Cl2N2O4S: 627.2, 629.2 (M+H+); found: 627.3, 629.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987250B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-bc6bc37aeb9243a59f4ef03b9f09fd2a |
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| Source note | uspto-grants-2015_03 |
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