2-Methyl-2-(4-methylphenyl)morpholine → HCID 86700411, compound

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Reaction Steps

(2S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-phenylmorpholino)benzo[d]thiazol-6-yl)acetic acid was prepared using the similar procedure as (2S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-(4-chlorophenyl)-2-methylmorpholino)-5-methylbenzo[d]thiazol-6-yl)acetic acid except 2-(4-methylphenyl)-2-methylmorpholine was used instead of 2-(4-chlorophenyl)-2-methylmorpholine. LCMS-ESI+: calc'd for C30H31ClN2O4S: 551.2, 553.2 (M+H+); found: 551.3, 553.3 (M+H+). 1H-NMR: 400 MHz, (CD3C1) δ: 7.62 (dd, J1=2.4 Hz, J2=10 Hz, 1H), 7.49 (m, 3H), 7.3-7.4 (m, 6H), 5.13 (s, 1H), 4.58 (d, J=10.8 Hz, 1H), 4.09 (m, 2H), 3.80 (m, 2H), 3.64 (m, 1H), 3.37 (m, 1H), 3.08 (dd, J1=12.8 Hz, J2=10.8 Hz, 1H. 50 (s, 3H), 2.49 (s, 3H), 0.93 (s, 9H).

Provenance & Evidence