Lithium Chloride → HCID 86700462, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-methyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (22 mg, 0.046 mmol) in dioxane (2 mL), was added 1-methyl-3-(4-methylpiperazin-1-yl)-5-(tributylstannyl)-1H-pyrazolo[4,3-b]pyridine (20 mg, 0.038 mmol), CuI (7 mg, 0.038 mmol), LiCl (8 mg, 0.19 mmol) and Pd(PPh3)4 (4.4 mg, 0.004 mmol). The reaction mixture was heated at 100° C. for 2 h. The reaction was cooled, washed with sat. NaHCO3, extracted with EtOAc, dried over MgSO4, filtered, concentrated down and purified by silica gel column, first eluting by 0-100% EtOAc in hexanes, then eluting by 0-20% MeOH in dichloromethane to give the product. LCMS-ESI+: calc'd for C33H37ClN6O3S: 633.2 (M+H+); Found: 633.3 (M+H+).

Provenance & Evidence