3-Pyridinylboronic acid → HCID 86700465, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-3-iodo-1-methyl-1H-pyrazolo[4,3-b]pyridine (104 mg, 0.354 mmol, containing the isomer 5-chloro-3-iodo-2-methyl-21-1-pyrazolo[4,3-b]pyridine) was added pyridin-3-ylboronic acid (52 mg, 0.425 mmol). The reaction mixture was heated at 70° C. for 1 hr. Then the temperature was raised to 90° C. and the reaction was stirred at 90° C. for 2 h. The reaction was cooled down, washed with sat. NaHCO3, extracted with EtOAc, dried over MgSO4, filtered, concentrated down and purified by silica gel column to give the product. LCMS-ESI+: calc'd for C12H9ClN4: 245.0 (M+H+); Found: 245.3 (M+H+).

Provenance & Evidence