Lithium Chloride → HCID 86700466, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-methyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (8 mg, 0.018 mmol) in dioxane (2 mL), was added 1-methyl-3-(pyridin-3-yl)-5-(tributylstannyl)-1H-pyrazolo[4,3-b]pyridine (9 mg, 0.018 mmol), CuI (3.4 mg, 0.018 mmol), LiCl (3.8 mg, 0.09 mmol) and Pd(PPh3)4 (2 mg, 0.002 mmol). The reaction mixture was heated at 100° C. for 2 h. The reaction was cooled, washed with sat. NaHCO3, extracted by EtOAc, dried over MgSO4, filtered, concentrated down and purified by silica gel column, eluting with 0-100% EtOAc in hexanes to give the product. LCMS-ESI+: calc'd for C33H30ClN5O3S: 612.2 (M+H+); Found: 612.2 (M+H+).

Provenance & Evidence