Sodium Hydroxide → HCID 86700468, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-3-(pyridin-3-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)benzo[d]thiazol-6-yl)acetate (6 mg, 0.01 mmol) in THF (0.5 mL) and MeOH (0.5 mL) was added 2N NaOH (100 μL). The reaction mixture was heated at 45° C. overnight. The reaction mixture was concentrated, the residue was dissolved in DMF and MeOH, filtered and purified by reverse phase HPLC (10-100% ACN/H2O+0.1% TFA) to give the product (3 mg). 1H NMR (400 MHz, CD3OD) δ 9.70 (bs, 1H), 8.97 (d, J=3.8 Hz, 1H), 8.60 (bs, 1H), 8.37 (d, J=4.4 Hz, 1H), 8.14 (d, J=4.2 Hz, 1H), 7.84-7.56 (m, 6H), 5.24 (s, 1H), 4.13 (s, 3H), 2.63 (s, 3H), 0.98 (s, 9H). LCMS-ESI+: calc'd for C32H28ClN5O3S: 598.2 (M+H+); Found: 598.2 (M+H+).

Provenance & Evidence